Determination of Zolmitriptan in Pharmaceutical Dosage Form

The spectrophotometric methods for the determination of Zolmitriptanin pure and dosage forms have been described in thispaper. The aim of the present work is to develop simple, sensitive and cost-effective spectrophotometric method for the determination of Zolmitriptan in pharmaceutical formulation. The present methods involve the determination of Zolmitriptanin pharmaceutical dosage at the given optimum conditions. The stock solution of Zolmitriptan was prepared by dissolving100 mg of the drug in 10.0 mL of methanol and made up to 100 mL with distilled water to get a clear solution. Appropriate volumes of this stock solution were diluted step wise to get the working standard solutions of concentrations 200μg/mL for MethodM13; 250 μg/mL for Method-M15; respectively. The proposed methods have the good sensitivity and higher λmax. Statistical analysis of the results showed that the proposed procedures have good precision and accuracy.